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KMID : 1123920060200051334
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Korean Journal of Oriental Physiology and Pathology
2006 Volume.20 No. 5 p.1334 ~ p.1336
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Effects of Herbal Extracts Used in Oriental Medicines on Heme Oxygenase-1 Expression
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Jeong Gil-Saeng
Oh Seung-Hwan
Kang Dae-Gill
Lee Ho-Sub
Kim Youn-Chul
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Abstract
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Effects of twenty-three aqueous herbal extracts used in oriental medicines on heme oxygenase (HO)-1 expression were estimated in a mouse hippocampal cell line, HT22. HO-1 is one of the cytoprotective enzymes activated various stimuli, and Western blot analysis was used for evaluated HO-1 expression. Six aqueous extracts such as Rhei Rhizoma, Paeoniae Radix, Uncariae Ramulus et Uncus, Theae Folium, Prunellae Spica, and Coptidis Rhizoma significantly increased HO-1 expression in HT22 cells at the concentration of 300 g/ml. In Addition, four aqueous extracts including Eucommiae Cortex, Moutan Cortex Radicis, Ginseng Radix Rubra, and Scutellariae Radix moderately increased HO-1 expression. These results would be usefulfor the isolation and identification of their neuroprotective principles.
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KEYWORD
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Heme oxygenase-1, HT22, Oriental medicine
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